Key result
The angiotensin converting enzyme gene I/D polymorphism was not associated with coronary artery disease in an Indian population (D/D genotype in 20.66% of patients vs 23.38% of controls).
Why the study?
Is the ACE gene I/D polymorphism associated with an increased risk of coronary artery disease in the Indian population?
Population
351 Indian subjects, comprising 150 patients with angiographically proven coronary artery disease and 201…
Comparison
Angiotensin converting enzyme gene I/D… vs Healthy controls
Design
Cross-sectional
Authors
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ACE I/D polymorphism lacks utility as CAD risk marker in Indians; leaves open ethnic differences in genetic associations.
Cross-Sectional (n=351)
Is the ACE gene I/D polymorphism associated with an increased risk of coronary artery disease in the Indian population?
The ACE gene I/D polymorphism is not a useful marker for coronary artery disease risk in the Indian population, despite its influence on serum ACE levels.
Joseph et al. (1998) conducted a cross-sectional in Coronary artery disease (n=351). Angiotensin converting enzyme gene I/D polymorphism vs. Healthy controls was evaluated on Association of ACE gene I/D polymorphism with coronary artery disease. The angiotensin converting enzyme gene I/D polymorphism was not associated with coronary artery disease in an Indian population (D/D genotype in 20.66% of patients vs 23.38% of controls).
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