Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1996Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Genotype Distribution of Angiotensin-Converting Enzyme Polymorphism in Australian Healthy and Coronary Populations and Relevance to Myocardial Infarction and Coronary Artery Disease

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is the ACE D/D genotype associated with an increased risk of coronary artery disease and myocardial infarction in an Australian white population?

Population

550 Australian white patients aged 37 to 65 years with angiographically documented coronary artery disease…

Comparison

Presence of the angiotensin-converting enzyme… vs ACE I/I or I/D genotypes, and healthy control…

Design

Case-control

Authors

XWX.L. WangNew South Wales Department of HealthRMR. M. McCredieSingapore General HospitalDWD. E. L. WilckenUNSW Sydney

Discussion

Loading...

Member takes

Implication

ACE D/D genotype associated with CAD/MI in case-control data; hypothesis-generating and should not yet change clinical risk assessment.

Structured PICO

Is the ACE D/D genotype associated with an increased risk of coronary artery disease and myocardial infarction in an Australian white population?

P
Population
550 Australian white patients aged 37 to 65 years with angiographically documented coronary artery disease, and 404 healthy school children aged 6 to 13 years.
I
Intervention
Presence of the angiotensin-converting enzyme (ACE) D/D genotype
C
Comparator
ACE I/I or I/D genotypes, and healthy control population
O
Outcome
Association of ACE genotype distribution with coronary artery disease and history of myocardial infarctionsurrogate

The ACE D/D genotype is a significant predictor for coronary artery disease events and myocardial infarction in the Australian white population, but does not correlate with angiographic disease severity.

Cite This Study

Wang et al. (1996) studied this question.

synapsesocial.com/papers/6a8832f24c82be800eeb4e38https://doi.org/10.1161/01.atv.16.1.115
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Converting Enzyme Genotype in Children and Coronary Events in Their Grandparents1995 · 66 citations
  2. 2Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction but Not With Development of Coronary Stenosis1995 · 175 citations
  3. 3Insertion /deletion (I/D) polymorphism at the locus for angiotensin I‐converting enzyme and parental history of myocardial infarction1993 · 59 citations
  4. 4A DNA Variant at the Angiotensin-Converting Enzyme Gene Locus Associates With Coronary Artery Disease in the Caerphilly Heart Study1995 · 177 citations
  5. 5Insertion/deletion (I/D) polymorphism at the locus for angiotensin I‐converting enzyme and myocardial infarction1993 · 107 citations