Key result
Early intervention within 24 hours for poor-grade aneurysmal subarachnoid hemorrhage significantly increased the odds of a favorable clinical outcome (OR 4.14; 95% CI 3.82-4.35).
Why the study?
Does early intervention (<24 hours) and treatment modality improve clinical outcomes in patients with poor-grade aneurysmal subarachnoid hemorrhage?
Cohort (n=79)
Does early intervention (<24 hours) and treatment modality improve clinical outcomes in patients with poor-grade aneurysmal subarachnoid hemorrhage?
Odds Ratio: 4.14 (95% CI 3.82–4.35)
Absolute Event Rate: 58% vs 22%
p-value: p=<0.039
Early intervention within 24 hours for poor-grade aneurysmal subarachnoid hemorrhage is associated with lower mortality and better functional outcomes compared to later treatment, with no significant difference between clipping and endovascular therapy.
Early intervention may improve outcomes in poor-grade aSAH; leaves open optimal timing and modality pending randomized confirmation.
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Tykocki et al. (2017) conducted a cohort in poor-grade aneurysmal subarachnoid hemorrhage (n=79). Early intervention (<24 hours) vs. Later intervention (≥24 hours) was evaluated on Favorable modified Rankin Scale (0-3) at discharge (OR 4.14, 95% CI 3.82-4.35, p=<0.039). Early intervention within 24 hours for poor-grade aneurysmal subarachnoid hemorrhage significantly increased the odds of a favorable clinical outcome (OR 4.14; 95% CI 3.82-4.35).
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