Key result
Patients with duodenal ulcer had significantly elevated plasma noradrenaline concentrations compared to normal subjects, which were not normalized by vagotomy.
Why the study?
Does vagotomy normalize elevated plasma noradrenaline concentrations in patients with duodenal ulcer?
Population
12 patients with duodenal ulcer and 12 normal subjects
Comparison
Vagotomy and intravenous infusion of adrenaline vs 12 normal subjects (controls)
Design
Case-control
Authors
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Elevated noradrenaline in duodenal ulcer may reflect persistent sympathetic dysregulation independent of vagal tone; hypothesis-generating for its role in pathogenesis.
Case-Control (n=24)
Does vagotomy normalize elevated plasma noradrenaline concentrations in patients with duodenal ulcer?
Elevated plasma noradrenaline in duodenal ulcer patients is not related to epigastric pain, as it is not normalized by vagotomy.
Christensen et al. (1979) conducted a case-control in Duodenal ulcer (n=24). Duodenal ulcer vs. Normal subjects was evaluated on Plasma noradrenaline concentrations. Patients with duodenal ulcer had significantly elevated plasma noradrenaline concentrations compared to normal subjects, which were not normalized by vagotomy.
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