Key result
Systemic hypertonic saline decreased baseline core temperature (36.5 vs 37.4 degrees C) and increased heat-escape behaviour, which were inhibited by central AT1 and V1 antagonists (P<0.05).
Brain angiotensin II and arginine vasopressin mediate the decrease in body core temperature and increase in heat-escape/cold-seeking behavior induced by systemic salt loading via central AT1 and V1 receptors.
Central AT1/V1 pathways mediate salt effects on thermoregulation in rodents; leaves open translation to human cardiovascular physiology.
Salt loading decreases body core temperature (T(core)) at neutral ambient temperature (26 degrees C) and increases heat-escape/cold-seeking behaviour in desalivated rats. In this study, we tested the hypothesis that brain angiotensin II (AII) and arginine vasopressin (AVP) are associated with these responses. Surgically desalivated rats (n = 28) were administered an injection (S.C., 10 ml kg(-1)) of either normal saline (154 mM, NS) or hypertonic saline (2500 mM, HS) following an intracerebroventricular injection (10 microl kg(-1)) of an AII AT(1)-receptor antagonist (candesartan, 5 microg microl(-1)), an AVP V(1)-receptor antagonist ((beta-mercapto-beta, beta-cyclopenta-methylene propionyl(1), O-Me-Tyr(2), Arg(8))-vasopressin, 0.5 microg microl(-1)), or normal saline (154 mM). Each rat was placed in a behaviour box, first at 26 degrees C for 1 h to allow the measurement of baseline T(core) and movement. The ambient temperature was then elevated to 40 degrees C for the next 2 h, during which time the rat was able to trigger a 0 degrees C air reward for 30 s by moving into a specific area of the box (operant behaviour). The S.C. HS significantly decreased baseline T(core) at 26 degrees C (36.5 +/- 0.1 degrees C) and increased counts of operant behaviour at 40 degrees C (57 +/- 3) compared with results obtained following S.C. NS injection (37.4 +/- 0.1 degrees C and 42 +/- 1, respectively). These responses to s.c. HS were inhibited by the intracerebroventricular injection of AT(1) (37.3 +/- 0.1 degrees C and 43 +/- 2, respectively; P < 0.05) and V(1) antagonists (37.2 +/- 0.2 degrees C and 42 +/- 2, respectively; P < 0.05), although administration of both antagonists with S.C. NS had no effect. These results suggest that brain AII and AVP are involved in the decrease in T(core) observed at neutral ambient temperature and the increase in heat-escape/cold-seeking behaviour in response to osmotic stimulation, via the central AT(1) and V(1) receptors, respectively
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Konishi et al. (2002) studied Osmotic stimulation and thermoregulation (n=28). Hypertonic saline and central AT1/V1 receptor antagonists vs. Normal saline (154 mM) was evaluated on Baseline core temperature at 26 degrees C (p=<0.05). Systemic hypertonic saline decreased baseline core temperature (36.5 vs 37.4 degrees C) and increased heat-escape behaviour, which were inhibited by central AT1 and V1 antagonists (P<0.05).
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