Key result
Intraventricular angiotensin II triggers hypothermia in rats, attenuated by sinoaortic denervation or vasopressin antagonists.
Why the study?
The mechanisms underlying the hypothermic effect of intraventricular angiotensin II in unanesthetized rats were not fully understood.
Does intraventricular angiotensin II reduce body temperature and metabolic rate via the baroreceptor reflex in rats?
Does intraventricular angiotensin II reduce body temperature and metabolic rate via the baroreceptor reflex in rats?
The hypothermic effect of centrally administered angiotensin II in rats is largely mediated by baroreflexive suppression of metabolism secondary to blood pressure elevation.
No takes yet. Share an insight, caveat, or question.
Does not alter clinical management; extends preclinical evidence for baroreflex involvement in angiotensin-mediated hypothermia.
Shido et al. (1985) studied Healthy (animal model) (n=26). Intraventricular Angiotensin II vs. Intraventricular saline, sinoaortic denervation, or intravenous AVP-antagonist was evaluated on Changes in colonic temperature, metabolic rate, blood pressure, and heart rate. Intraventricular injection of angiotensin II produced hypothermia in rats, which was significantly attenuated by sinoaortic denervation or vasopressin antagonist pretreatment.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: