Key result
Russell's viper venom (Stypven) does not correct the prolonged one-stage prothrombin time of plasma deficient in Stuart factor, distinguishing it from Prower factor and factor VII deficiencies.
Why the study?
Does Russell's viper venom (Stypven) correct the prolonged one-stage prothrombin time in a patient with Stuart factor deficiency?
Population
1 patient with a congenital hemorrhagic diathesis previously thought to be deficient in factor VII
Comparison
In vitro application of Russell's viper venom vs Plasma deficient in Prower factor or factor VII
Design
Other
Authors
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Stypven assays may lack factor VII specificity; leaves open need for factor-specific testing in coagulopathy diagnosis.
Does Russell's viper venom (Stypven) correct the prolonged one-stage prothrombin time in a patient with Stuart factor deficiency?
Russell's viper venom does not correct Stuart factor deficiency, indicating that Stypven-based prothrombin assays are not specific for factor VII and also measure Stuart factor.
Cecil Hougie (1956) studied Congenital hemorrhagic diathesis (Stuart Clotting Defect) (n=1). Russell's viper venom (Stypven) vs. Prower factor and factor VII deficient plasma was evaluated on Correction of prolonged one-stage prothrombin time. Russell's viper venom (Stypven) does not correct the prolonged one-stage prothrombin time of plasma deficient in Stuart factor, distinguishing it from Prower factor and factor VII deficiencies.
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