Key result
Specific mutations in clotting factors FII, FVII, and FIX cause paradoxical thrombophilia and venous thrombosis.
Design
Review
Authors
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Challenges binary pro- vs antithrombotic classification of vitamin K factors; leaves open any change to clinical risk assessment or management.
This review highlights that specific mutations in vitamin K-dependent clotting factors FII, FVII, and FIX can lead to venous thrombosis, challenging the traditional view that they are exclusively prohemorrhagic.
Girolami et al. (2018) conducted a review in Vitamin K-dependent coagulation factor defects. Mutations in FII, FVII, and FIX was evaluated. Specific mutations in vitamin K-dependent clotting factors FII, FVII, and FIX, traditionally associated with bleeding, have been demonstrated to cause thrombophilic states and venous thrombosis.
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