Key result
Prolonged PR interval greater than 200 msec independently predicted new occurrence of atrial fibrillation (HR 1.950) in patients with frequent premature atrial contractions.
Why the study?
Does a prolonged PR interval predict new occurrence of atrial fibrillation in patients with frequent premature atrial contractions?
Cohort (n=684)
No
Does a prolonged PR interval predict new occurrence of atrial fibrillation in patients with frequent premature atrial contractions?
Hazard Ratio: 1.95 (95% CI 1.029–3.698)
Absolute Event Rate: 24.1% vs 8%
p-value: p=0.041
In patients with frequent premature atrial contractions, a prolonged PR interval is an independent predictor of new-onset atrial fibrillation.
Prolonged PR interval may flag higher AF risk in frequent PAC patients; leaves open need for prospective validation before clinical use.
The clinical significance of prolonged PR interval has not been evaluated in patients with frequent premature atrial contractions (PACs). We investigated whether prolonged PR interval could predict new occurrence of atrial fibrillation (AF) in patients with frequent PACs. We retrospectively analyzed 684 patients with frequent PACs (> 100 PACs/day) who performed repeated 24-hour Holter monitoring. Prolonged PR interval was defined as longer than 200 msec. Among 684 patients, 626 patients had normal PR intervals (group A) and 58 patients had prolonged PR intervals (group B). After a mean follow-up of 59.3 months, 14 patients (24.1%) in group B developed AF compared to 50 patients (8.0%) in group A (P < 0.001). Cox regression analysis showed that prolonged PR interval (hazard ratio [HR], 1.950; 95% CI, 1.029-3.698; P = 0.041), age (HR, 1.033; 95% CI, 1.006-1.060; P = 0.015), and left atrial (LA) dimension (HR, 1.061; 95% CI, 1.012-1.112; P = 0.015) were associated with AF occurrence. Prolonged PR interval, advanced age, and enlarged LA dimension are independent risk factors of AF occurrence in patients with frequent PACs.
No takes yet. Share an insight, caveat, or question.
Chun et al. (2016) conducted a cohort in Frequent premature atrial contractions (n=684). Prolonged PR interval (> 200 msec) vs. Normal PR interval (≤ 200 msec) was evaluated on New occurrence of atrial fibrillation (HR 1.950, 95% CI 1.029-3.698, p=0.041). Prolonged PR interval greater than 200 msec independently predicted new occurrence of atrial fibrillation (HR 1.950) in patients with frequent premature atrial contractions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: