Association between PR interval prolongation and electro-anatomical substrate in patients with atrial fibrillation
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Why the study?
Is PR interval prolongation associated with the presence of low voltage areas (electro-anatomical substrate) in patients with atrial fibrillation undergoing catheter ablation?
Population
n=103 consecutively selected AF patients undergoing first AF radiofrequency catheter ablation at the Heart…
Comparison
PR interval prolongation on resting ECG before… vs Patients without PR interval prolongation
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
PR prolongation may flag LA substrate in AF; leaves open whether it refines ablation risk stratification.
Structured PICO
Is PR interval prolongation associated with the presence of low voltage areas (electro-anatomical substrate) in patients with atrial fibrillation undergoing catheter ablation?
P
Population
n=103 consecutively selected AF patients undergoing first AF radiofrequency catheter ablation at the Heart Center Leipzig and presenting in sinus rhythm. Mean age 62, 59% male, 34% persistent AF. Exclusions: pregnancy, age <18 or >75, valvular AF, cancer, acute or systemic inflammatory diseases.
I
Intervention
PR interval prolongation (>200ms) on resting ECG before intervention
C
Comparator
Patients without PR interval prolongation (PR ≤200ms)
O
Outcome
Presence of low voltage areas (LVA) defined as <0.5 mV determined using high-density electro-anatomical mapping during catheter ablationsurrogate
PR interval prolongation on surface ECG is associated with advanced left atrial electro-anatomical remodeling (low voltage areas) and may serve as a non-invasive predictor of substrate in AF patients.
Limitations
- relatively small number of patients
- small numbers of patients with PR prolongation and LVA
- impact of AV-nodal blocking medication on PR interval prolongation needs to be considered
Cite This Study
Schumacher et al. (2018) studied this question.
Topics
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