Key result
Daily subcutaneous injections of thyroxine completely restored acute volume expansion-induced release of atrial natriuretic peptides in hypophysectomized rats.
Why the study?
Does thyroxine restore atrial stretch-induced secretion of atrial natriuretic peptide in hypophysectomized rats?
Does thyroxine restore atrial stretch-induced secretion of atrial natriuretic peptide in hypophysectomized rats?
Thyroid hormone is required for the secretion of atrial natriuretic peptide in response to acute volume expansion in a rat model.
Thyroid hormone may be required for ANP release after volume expansion in rats; leaves open human relevance and does not support clinical practice change.
Acute blood volume expansion caused a rapid and profound release of atrial natriuretic peptides (ANP) from cardiac atria. The stimulated release of ANP was markedly blunted (more than 50%) in hypophysectomized rats (8 days after surgery). Daily subcutaneous injections of thyroxine (30 micrograms/kg) to hypophysectomized rats for 7 days, completely restored acute volume expansion induced release of ANP. Our data suggest that thyroid hormone is required for ANP secretion in response to acute volume expansion.
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Zamir et al. (1993) studied Hypophysectomized rats. Thyroxine vs. Hypophysectomized rats without thyroxine was evaluated on Acute volume expansion induced release of atrial natriuretic peptides (ANP). Daily subcutaneous injections of thyroxine completely restored acute volume expansion-induced release of atrial natriuretic peptides in hypophysectomized rats.
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