Key result
Intact parathyroid glands in rats yield ~159% higher plasma ANP after volume expansion versus hypocalcemic parathyroidectomy.
Why the study?
The role of parathyroid hormone and extracellular calcium in modulating atrial natriuretic peptide release during acute volume expansion was unclear.
Does parathyroid hormone modulate the release of atrial natriuretic peptide during acute volume expansion in rats?
Does parathyroid hormone modulate the release of atrial natriuretic peptide during acute volume expansion in rats?
Absolute Event Rate: 702% vs 271%
p-value: p=<0.001
Parathyroid hormone appears to be required for augmented ANP secretion in response to acute volume loading in a rat model, suggesting a parathyroid-cardiac atria interaction in fluid homeostasis.
Suggests PTH dependence of ANP release in rat volume expansion; leaves open any human relevance or clinical implications.
In this study we investigated the effect of volume expansion on plasma and atrial concentrations of atrial natriuretic peptide (ANP) in the presence and absence of the parathyroid gland and under normocalcemic and hypocalcemic conditions. After volume expansion ANP concentration in plasma was significantly (p < 0.001) higher in intact (702 +/- 86 pg/ml) than in hypocalcemic parathyroidectomized (PTX) (271 +/- 38 pg/ml) rats. Plasma ANP of PTX rats rendered normocalcemic with oral calcium supplementation increased to 402 +/- 85 pg/ml after volume expansion. Results from this study suggest that parathyroid hormone (PTH) is required for augmented ANP secretion in response to acute volume loading and alterations of extracellular calcium may modulate volume-induced ANP release in PTX rats. We would discuss that a parathyroid gland-cardiac atria interaction exists and that changes in serum level of PTH may play a role in the regulation of fluid homeostasis via ANP secretion.
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Geiger et al. (1992) studied this question. Intact parathyroid gland vs. Hypocalcemic parathyroidectomized (PTX) rats was evaluated on Plasma ANP concentration after volume expansion (p=<0.001). Intact parathyroid glands in rats resulted in significantly higher plasma ANP concentrations after acute volume expansion compared to hypocalcemic parathyroidectomized rats (702 vs 271 pg/ml, p<0.001).
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