Key result
Childhood cancer was associated with a substantially increased relative risk of venous thromboembolism compared to children without cancer (HR 28.3; 95% CI 7.0-114.5).
Why the study?
Does childhood cancer increase the risk of venous thromboembolism compared to children without cancer?
Cohort (n=21,308)
Yes
Does childhood cancer increase the risk of venous thromboembolism compared to children without cancer?
Hazard Ratio: 28.3 (95% CI 7–114.5)
Absolute Event Rate: 1.52% vs 0.06%
Children with cancer have a substantially increased relative risk of VTE compared to those without cancer, though the absolute risk remains extremely small.
Supports heightened VTE vigilance in childhood cancer; leaves open whether prophylaxis alters outcomes.
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Walker et al. (2013) conducted a cohort in Cancer (n=21,308). Childhood cancer vs. No cancer was evaluated on Venous thromboembolism (VTE) (HR 28.3, 95% CI 7.0-114.5). Childhood cancer was associated with a substantially increased relative risk of venous thromboembolism compared to children without cancer (HR 28.3; 95% CI 7.0-114.5).
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