Key result
The rs2274907 polymorphism of the omentin gene was not significantly associated with type 2 diabetes in the Iranian population.
Why the study?
Omentin is an adipose tissue protein associated with diabetes, but the relationship between the omentin-1 gene rs2274907 polymorphism and diabetes required investigation.
Is the rs2274907 polymorphism of the omentin gene associated with type 2 diabetes in an Iranian population?
Case-Control (n=140)
Yes
Is the rs2274907 polymorphism of the omentin gene associated with type 2 diabetes in an Iranian population?
p-value: p=>0.05
This study found no significant association between the rs2274907 polymorphism of the omentin gene and type 2 diabetes in an Iranian population.
No T2D link in this Iranian cohort; leaves open population-specific omentin effects and requires larger studies.
Background: Diabetes is one of the most common chronic metabolic diseases in the world that is caused by decreased insulin secretion or insulin resistance and fat accumulation in visceral adipose tissue (IR).Omentin is a protein inferred from adipose tissue that is associated with the rate of diabetes.The aim of this study was to investigate the relationship between rs2274907 polymorphism of amentine-1 gene with diabetes.Materials and methods: This case-control study was conducted on 70 patients with diabetes and 70 healthy individuals as control.FBS, TG, CHOL, HDL, and LDL were measured in the subjects and genotype determination was performed using PCR-RFLP.Results: Age, body mass index, LDL, cholesterol, triglyceride, fasting high sugar and insulin resistance were significantly different between patients and healthy individuals (p<0.05).No significant difference was observed in omentin level in diabetic compared to control patients (p>0.05).Omentin levels in different genotypes rs2274907 were different in healthy subjects, but the difference was not significant.Omentin levels in different genotypes rs2274907 were different in healthy subjects (p<0.05).Genotype regression analysis showed that genotypes in rs2274907 polymorphism were not related to diabetes (p>0.05).Conclusion: This study revealed that there was no significant relationship between rs2274907 genotype and type 2 diabetes.
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Nazari et al. (2022) conducted a case-control in Type 2 diabetes (n=140). rs2274907 polymorphism of omentin gene vs. Healthy controls was evaluated on Association of rs2274907 polymorphism with type 2 diabetes (p=>0.05). The rs2274907 polymorphism of the omentin gene was not significantly associated with type 2 diabetes in the Iranian population.
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