Key result
Laparoscopic sleeve gastrectomy significantly increased serum omentin levels and decreased omentin mRNA expression in subcutaneous adipose tissue of obese women.
Why the study?
Do weight loss interventions (very-low-calorie diet, physical activity, or laparoscopic sleeve gastrectomy) alter serum omentin levels and subcutaneous adipose tissue mRNA expression in obese women with or without type 2 diabetes?
Cohort (n=74)
No
Do weight loss interventions (very-low-calorie diet, physical activity, or laparoscopic sleeve gastrectomy) alter serum omentin levels and subcutaneous adipose tissue mRNA expression in obese women with or without type 2 diabetes?
Absolute Event Rate: 455.7% vs 358.1%
p-value: p=<0.05
Laparoscopic sleeve gastrectomy, but not short-term diet or exercise, significantly increases circulating omentin levels in obese women, which may contribute to surgery-induced metabolic improvements.
No takes yet. Share an insight, caveat, or question.
LSG-linked omentin shifts remain hypothesis-generating; observational data leaves open any causal metabolic role pending RCTs.
Urbanová et al. (2014) conducted a cohort in Morbid obesity and Type 2 Diabetes Mellitus (n=74). Laparoscopic sleeve gastrectomy, very-low-calorie diet, and physical activity vs. Baseline (pre-intervention) was evaluated on Serum omentin levels at 6 months after laparoscopic sleeve gastrectomy (p=<0.05). Laparoscopic sleeve gastrectomy significantly increased serum omentin levels and decreased omentin mRNA expression in subcutaneous adipose tissue of obese women.
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