Key result
Elective cardiac surgery increased serum omentin levels from 636 to 774 ng/ml in patients without coronary artery disease and diabetes, but not in those with these conditions.
Why the study?
Omentin levels are decreased in obesity, type 2 diabetes mellitus, and CAD, and experimental studies suggest it has anti-inflammatory and insulin-sensitizing properties.
Does elective cardiac surgery affect omentin levels and mRNA expression differently in patients with or without coronary artery disease and type 2 diabetes?
Observational (n=38)
No
Does elective cardiac surgery affect omentin levels and mRNA expression differently in patients with or without coronary artery disease and type 2 diabetes?
Cardiac surgery increases serum omentin levels and subcutaneous fat/skeletal muscle mRNA expression only in patients without CAD and diabetes, suggesting a blunted protective stress response in patients with metabolic and cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Cardiac surgery alters omentin levels and expression differently by CAD/DM status; leaves open any clinical relevance or therapeutic targeting.
Omentin is a protein produced by numerous tissues including adipose tissue. Its concentrations are decreased in patients with obesity, type 2 diabetes mellitus (DM) and coronary artery disease (CAD). Experimental studies suggest that omentin may have anti-inflammatory and insulin-sensitizing properties. In the present study, we measured circulating omentin levels and its mRNA expression in epicardial and subcutaneous fat, intercostal and heart muscle before and after elective cardiac surgery in patients with CAD (CAD+, DM-, n=18), combination of CAD and DM (CAD+, DM+, n=9) or with none of these conditions (CAD-, DM-, n=11). The groups did not differ in baseline anthropometric and biochemical characteristics with the exception of higher blood glucose and HBA(1c) in CAD+, DM+ group. Baseline circulating omentin levels tended to be lower in CAD+, DM- and CAD+, DM+ groups as compared to CAD-, DM- group and cardiac surgery increased its concentration only in CAD-, DM- group. The change in serum omentin levels during surgery inversely correlated with epicardial fat thickness. While baseline omentin mRNA expression did not differ among the groups in any of the studied tissues, its increase after surgery was present only in subcutaneous fat in CAD-, DM- and CAD+, DM- groups, but not in CAD+, DM+ group. Intercostal muscle omentin mRNA expression increased after surgery only in CAD-, DM- group. In conclusion, cardiac surgery differentially affects omentin levels and subcutaneous fat and skeletal muscle mRNA expression in patients without coronary artery disease and diabetes as compared to patients with these conditions.
No takes yet. Share an insight, caveat, or question.
Matloch et al. (2018) conducted an observational in Coronary artery disease and type 2 diabetes in patients undergoing cardiac surgery (n=38). Elective cardiac surgery vs. Baseline (pre-surgery) was evaluated on Serum omentin levels at the end of surgery compared to baseline in patients without CAD and DM (p=<0.05). Elective cardiac surgery increased serum omentin levels from 636 to 774 ng/ml in patients without coronary artery disease and diabetes, but not in those with these conditions.
Synapse has enriched 10 related papers. Consider them for comparative context: