Key result
Higher blood levels of macrophage migration inhibitory factor (MIF) were significantly associated with the need for surgical revision due to microanastomosis thrombosis after free flap surgery.
Why the study?
Thrombosis of the microanastomosis remains a fatal complication after microsurgical free flap surgery, and macrophage migration inhibitory factor (MIF) could help predict vascular compromise and failure of flap perfusion.
Does Macrophage migration inhibitory factor (MIF) predict thrombosis of the microanastomosis after microsurgical reconstruction?
Observational (n=26)
Does Macrophage migration inhibitory factor (MIF) predict thrombosis of the microanastomosis after microsurgical reconstruction?
Answers are grounded in this paper and cite their sources.
MIF is a potential biomarker for detecting thrombosis of the microanastomosis after free flap surgery.
(1) Background: Nowadays, the use of microsurgical free flaps is a standard operative procedure in reconstructive surgery. Still, thrombosis of the microanastomosis is one of the most fatal postoperative complications. Clinical evaluation, different technical devices and laboratory markers are used to monitor critical flap perfusion. Macrophage migration inhibitory factor (MIF), a structurally unique cytokine with chemokine-like characteristics, could play a role in predicting vascular problems and the failure of flap perfusion. (2) Methods: In this prospective observational study, 26 subjects that underwent microsurgical reconstruction were observed. Besides clinical data, the number of blood leukocytes, CRP and MIF were monitored. (3) Results: Blood levels of MIF, C-reactive protein (CRP) and leukocytes increased directly after surgery. Subjects that needed surgical revision due to thrombosis of the microanastomosis showed significantly higher blood levels of MIF than subjects without revision. (4) Conclusion: We conclude that MIF is a potential and innovative indicator for thrombosis of the microanastomosis after free flap surgery. Since it is easy to obtain diagnostically, MIF could be an additional tool to monitor flap perfusion besides clinical and technical assessments.
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Megas et al. (2021) conducted an observational in microsurgical reconstruction (n=26). Macrophage migration inhibitory factor (MIF) levels vs. Lower MIF levels was evaluated on surgical revision due to thrombosis of the microanastomosis. Higher blood levels of macrophage migration inhibitory factor (MIF) were significantly associated with the need for surgical revision due to microanastomosis thrombosis after free flap surgery.
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