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August 1, 1985AJP Heart and Circulatory Physiology

Biaxial mechanical properties of the pericardium in normal and volume overload dogs

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Key result

Chronic cardiac dilatation resulted in a more compliant pericardium, with tension-stretch curves shifted significantly to the right compared to normal dogs.

Population

Dogs with normal hearts and dogs with chronic cardiac dilatation due to an infrarenal aortocaval shunt

Comparison

Chronic cardiac dilatation induced by infrarenal… vs Normal dogs without cardiac dilatation

Design

Preclinical

Authors

MLM. C. LeeLos Alamos National LaboratoryMLM. M. LeWinterHershey (United States)GFG. L. FreemanThe University of Texas Health Science Center at San Antonio

Discussion

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Implication

Indicates pericardial adaptation in canine dilatation models; leaves open relevance to human constraint or clinical practice.

Structured PICO

P
Population
Dogs with normal hearts or chronic cardiac dilatation due to an infrarenal aortocaval shunt.
E
Exposure
Chronic cardiac dilatation induced by infrarenal aortocaval shunt
C
Comparator
Normal dogs without cardiac dilatation
O
Outcome
Biaxial mechanical properties of the pericardium (tension-stretch relationship, compliance, viscoelastic properties, thickness)surrogate

Chronic cardiac dilatation in a dog model results in a more compliant pericardium without changes in thickness or viscoelastic properties.

Cite This Study

Lee et al. (1985) studied Chronic cardiac dilatation (volume overload). Chronic cardiac dilatation vs. Normal heart was evaluated on Biaxial mechanical properties (tension-stretch relationship). Chronic cardiac dilatation resulted in a more compliant pericardium, with tension-stretch curves shifted significantly to the right compared to normal dogs.

synapsesocial.com/papers/6a9fddb93a35f4a2c890e229https://doi.org/10.1152/ajpheart.1985.249.2.h222
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pericardial adaptations during chronic cardiac dilation in dogs.1984 · 104 citations
  2. 2In vivo mechanical behavior of canine pericardium1986 · 14 citations
  3. 3Mechanical properties of human pericardium. Differences in viscoelastic response when compared with canine pericardium.1985 · 89 citations
  4. 4Viscoelastic properties of the diastolic left ventricle in the conscious dog.1977 · 189 citations
  5. 5Ventricular diastolic pressure-volume relations and the pericardium. Effects of changes in blood volume and pericardial effusion in dogs.1981 · 64 citations