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September 1, 1985Circulation ResearchOpen Access

Mechanical properties of human pericardium. Differences in viscoelastic response when compared with canine pericardium.

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Why the study?

Do the mechanical properties of human pericardium differ from those of canine pericardium?

Population

Fresh human pericardium and canine pericardium

Comparison

Tensile viscoelastic property testing vs Canine pericardium

Design

Preclinical

Authors

JLJ M LeeRJ Lee Group (United States)DBDerek R. BoughnerWestern University

Discussion

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Implication

Human-canine pericardial differences caution against extrapolating canine mechanics to humans; leaves open need for human-specific models in dynamic studies.

Structured PICO

Do the mechanical properties of human pericardium differ from those of canine pericardium?

P
Population
Fresh human pericardium and canine pericardium
I
Intervention
Tensile viscoelastic property testing
C
Comparator
Canine pericardium
O
Outcome
Tensile viscoelastic properties (viscous character, thickness, extensibility, stiffness)surrogate

Human pericardium has significantly different viscoelastic properties compared to canine pericardium, suggesting canine models may not be directly applicable to humans for dynamic mechanical studies.

Cite This Study

Lee et al. (1985) studied this question.

synapsesocial.com/papers/6a8261ca2beaf6c72d8783a1https://doi.org/10.1161/01.res.57.3.475
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biaxial mechanical properties of the pericardium in normal and volume overload dogs1985 · 64 citations
  2. 2Mechanical Response of the Cross-Linked Pericardial Tissue2013
  3. 3In vivo mechanical behavior of canine pericardium1986 · 14 citations
  4. 4Influence of inflammation and cardiac hypertrophy on mechanical properties of human pericardium2022
  5. 5Anisotropic elasticity of bovine pericardial tissues.1985 · 15 citations