Key result
Inflammation and cardiac hypertrophy did not correlate with the mechanical properties (load or strain at fracture) of human pericardium.
Why the study?
To evaluate the pericardial sac as an implantation site for mechanical circulatory support, further knowledge about the mechanical properties of human pericardium was required.
Do inflammation and cardiac hypertrophy influence the mechanical properties of human pericardium?
Population
56 samples of human pericardium extracted postmortem from 13 critically ill patients
Design
Prospective, monocentric, experimental pilot study
Authors
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May support pericardial use for devices despite inflammation; leaves open human validation.
Observational (n=13)
No
Do inflammation and cardiac hypertrophy influence the mechanical properties of human pericardium?
Inflammation and cardiac hypertrophy do not appear to influence the mechanical properties of human pericardium, supporting its potential viability as an implantation site for mechanical circulatory support devices.
Schott et al. (2022) conducted an observational in Critically ill patients (n=13). Inflammation and cardiac hypertrophy was evaluated on Load at fracture per sample width and strain at fracture. Inflammation and cardiac hypertrophy did not correlate with the mechanical properties (load or strain at fracture) of human pericardium.
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