Key result
Carotid chemoreceptor-mediated excitation of expiratory bulbospinal neurones is dependent on NMDA but not non-NMDA glutamate receptors, as AP5 reduced the change in discharge frequencies.
Population
Thiopental sodium anaesthetized, paralysed, ventilated, vagotomized dogs
Comparison
Pressure microejection of the NMDA receptor… vs Baseline and bolus expiratory neuronal discharge…
Design
Preclinical
Authors
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Identifies NMDA receptor dependence in canine chemoreflex pathways; leaves open translation to human ventilatory control or therapies.
Carotid chemoreceptor-mediated excitation of expiratory bulbospinal neurones in dogs is dependent on NMDA, but not non-NMDA, glutamate receptors.
Stuth et al. (1995) studied this question. AP5 (NMDA receptor antagonist) and NBQX (non-NMDA receptor antagonist) vs. Baseline/control cycles was evaluated on Net responses of expiratory bulbospinal neurones to peripheral chemoreceptor activation (change in mean discharge frequencies). Carotid chemoreceptor-mediated excitation of expiratory bulbospinal neurones is dependent on NMDA but not non-NMDA glutamate receptors, as AP5 reduced the change in discharge frequencies.
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