Key result
Coronary arterial perfusion with a perfluorochemical substance returned myocardial function and metabolism toward control states following 10 minutes of ischemia in dogs, though diastolic properties were not completely restored.
Why the study?
Does coronary arterial perfusion with perfluorotributylamine improve myocardial function and metabolism following ischemia in a canine model?
Does coronary arterial perfusion with perfluorotributylamine improve myocardial function and metabolism following ischemia in a canine model?
In a canine model of acute myocardial ischemia, reperfusion with a perfluorochemical emulsion partially restored myocardial function and metabolism, suggesting potential utility for protecting ischemic myocardium.
Does not support clinical use of perfluorochemical perfusion; leaves open translational studies on diastolic recovery after ischemia.
The effects of coronary arterial perfusion with a perfluorochemical substance (perfluorotributylamine) on the segmental myocardium of the beating heart were studied in 12 open chest anesthetized dogs. Following 10 min of left anterior descending coronary artery occlusion, perfusion of the coronary artery with the perfluorochemical returned myocardial function and metabolism toward control states, although myocardial diastolic properties as well as coronary venous PCO2 and lactate were not restored completely within 7 min after reperfusion. Perfluorochemicals may be of clinical importance in protecting the ischemic myocardium because of their oxygen carrying capacity together with favorable physiochemical properties for protection of the microcirculation.
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Haruo Tomoda (1985) studied Myocardial ischemia (n=22). Perfluorochemical substance (FC-43, perfluorotributylamine) vs. Blood reperfusion was evaluated on Myocardial function and metabolism (including segmental contraction and diastolic properties). Coronary arterial perfusion with a perfluorochemical substance returned myocardial function and metabolism toward control states following 10 minutes of ischemia in dogs, though diastolic properties were not completely restored.
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