Key result
Despite a significantly prolonged decrease in mean arterial pressure and serum ACE activity with spirapril, no marked differences in regional blood flow were noted between spirapril and captopril.
Why the study?
Does spirapril improve regional blood flow compared to captopril in patients with mild to moderate congestive heart failure?
Population
18 patients with mild to moderate congestive heart failure
Comparison
Spirapril (a long-acting ACE inhibitor) vs Captopril (a short-acting ACE inhibitor)
Design
Cohort
Follow-up
12 weeks
Authors
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Spirapril was not associated with regional blood flow differences versus captopril in mild-moderate HF; leaves open whether ACE inhibitor duration affects perfusion.
Does spirapril improve regional blood flow compared to captopril in patients with mild to moderate congestive heart failure?
Spirapril provides prolonged ACE inhibition and blood pressure reduction compared to captopril, but this does not translate into significant differences in regional blood flow in patients with mild to moderate heart failure.
Broek et al. (1995) studied mild to moderate congestive heart failure (CHF) (n=18). Spirapril vs. Captopril was evaluated on Regional blood flow (calf, renal, hepatic, and cerebral). Despite a significantly prolonged decrease in mean arterial pressure and serum ACE activity with spirapril, no marked differences in regional blood flow were noted between spirapril and captopril.
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