Key result
Acclimatization to 3,800 m altitude initially increased cardiac output in young subjects, but after 3-4 weeks, cardiac output was slightly below sea level values at rest and during work.
Why the study?
How does acclimatization to 3,800 m altitude affect cardiac output during rest and work in humans?
Population
5 human subjects (including young and old subjects)
Comparison
Acclimatization to 3,800 m altitude for 3-4 weeks vs Baseline values at sea level
Design
Other
Follow-up
3-4 weeks
Authors
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Warrants caution extrapolating acute altitude responses to chronic exposure; leaves open effects on exercise capacity or patients with heart disease.
Observational (n=5)
How does acclimatization to 3,800 m altitude affect cardiac output during rest and work in humans?
Cardiac output initially increases upon exposure to high altitude but falls slightly below sea level baseline after 3-4 weeks of acclimatization.
Kurt Klaudi Klausen (1966) conducted an observational in Acclimatization to high altitude (n=5). Acclimatization to 3,800 m altitude vs. Sea level was evaluated on Cardiac output (Q) at rest and work. Acclimatization to 3,800 m altitude initially increased cardiac output in young subjects, but after 3-4 weeks, cardiac output was slightly below sea level values at rest and during work.
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