Key result
Prior percutaneous coronary intervention was not associated with increased hospital mortality in patients undergoing surgical myocardial revascularization (OR 0.90; 95% CI 0.39-2.08; P=0.81).
Why the study?
Does prior PCI increase hospital mortality in adult patients undergoing CABG?
Cohort (n=3,641)
Yes
Does prior PCI increase hospital mortality in adult patients undergoing CABG?
Odds Ratio: 0.9 (95% CI 0.39–2.08)
p-value: p=0.81
Prior PCI does not appear to significantly increase hospital mortality in patients undergoing CABG in a contemporary European cohort, though meta-analysis suggests a possible trend toward higher risk.
Prior PCI not linked to higher early CABG mortality or morbidity in this cohort; leaves open long-term prognostic impact.
Background— The clinical impact of prior percutaneous coronary intervention (PCI) in patients requiring coronary artery bypass grafting (CABG) remains unsettled. We sought to determine whether prior PCI is associated with adverse outcome after CABG. Methods and Results— Data from the prospective E-CABG (European Multicenter Study on Coronary Artery Bypass Grafting) conducted between January 2015 and March 2016 at 16 European centres were analyzed using propensity weighted methodology to adjust for confounding. A parallel systematic review/meta-analysis (MEDLINE, Embase, SCOPUS, and Cochrane Library) through September 2017 was accomplished. Of a total of 3641 adult patients included in the E-CABG study, 685 (19%) patients had a history of PCI. At multivariable level, prior PCI was not associated with an increased hospital mortality in both unweighted and weighted patient groups (odds ratio, 0.73; 95% confidence interval, 0.29–1.38; P =0.33 and odds ratio, 0.90; 95% confidence interval, 0.39–2.08; P =0.81, respectively). Subgroup analyses confirmed that prior PCI had no impact on hospital mortality and morbidity, including reexploration for bleeding, blood transfusion, hospital resource use, and neurological, renal, and cardiac complications. The systematic review provided a total of 71 366 individuals and showed a trend toward higher in-hospital/30-day mortality (adjusted odds ratio, 1.30; 95% confidence interval, 0.99–1.70; I 2 =43.1%) in patients with prior PCI. Conclusions— Our prospective multicenter study showed that prior PCI was not associated with an increased risk of mortality or other adverse outcomes in patients undergoing CABG. In light of a trend toward increased mortality observed in the meta-analysis, further studies are needed to ascertain the prognostic impact of prior PCI in the outcome after CABG. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT02319083.
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Mariscalco et al. (2018) conducted a cohort in Coronary artery disease requiring CABG (n=3,641). Prior percutaneous coronary intervention (PCI) vs. No prior PCI was evaluated on Hospital mortality (OR 0.90, 95% CI 0.39-2.08, p=0.81). Prior percutaneous coronary intervention was not associated with increased hospital mortality in patients undergoing surgical myocardial revascularization (OR 0.90; 95% CI 0.39-2.08; P=0.81).
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