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September 8, 2026Veterinary SurgeryOpen Access

Intranasal xylometazoline hydrochloride to reduce intraoperative nasal hemorrhage in dogs undergoing ala‐vestibuloplasty for BOAS : A prospective, randomized study

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Authors

JSJun‐Yan SekAHArthur HouseTETheophilus I. Emeto

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Overview

Randomized placebo-controlled trial demonstrates reduced intraoperative bleeding in dogs undergoing ala-vestibuloplasty, indicating improved surgical visualization and safety.

Key Points

  • To assess whether preoperative intranasal administration of 0.1% xylometazoline hydrochloride reduces intraoperative hemorrhage during ala-vestibuloplasty in dogs with brachycephalic obstructive airway syndrome (BOAS).
  • Prospective, randomized, placebo-controlled clinical trial involving 30 client-owned brachycephalic dogs undergoing surgery for BOAS with ala-vestibuloplasty.
  • Dogs were randomly assigned to receive either intranasal 0.1% xylometazoline hydrochloride (n=17) or 0.9% saline placebo (n=13) before surgery.
  • Hemorrhage was measured gravimetrically by weighing cotton-tipped applicators and swabs; secondary endpoints included bodyweight-normalized blood loss, time to hemostasis, and rescue hemostatic interventions.
  • Median total intraoperative hemorrhage was 62% lower with xylometazoline than saline: 6.27 g (IQR: 4.57–7.45 g) versus 16.49 g (IQR: 15.15–25.47 g); p < .0001, corresponding to estimated blood volumes of 5.9 mL versus 15.6 mL.
  • Bodyweight-normalized hemorrhage (0.69 g/kg vs. 1.74 g/kg; p < .0001) and estimated percentage blood volume loss (0.76% vs. 1.93%; p < .0001) were significantly lower with xylometazoline.
  • Median time to hemostasis was shorter with xylometazoline (14.0 vs. 20.0 min; p = .0001), and rescue hemostatic intervention was required in 0/17 xylometazoline-treated dogs compared to 10/13 saline-treated dogs (p < .001).

Cite This Study

Sek et al. (2026) studied this question.

synapsesocial.com/papers/6aa0091858e84d0ff5b47c1fhttps://doi.org/10.1111/vsu.70155
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of 0.1% Xylometazoline-Hydrochloride Nasal Decongestant Spray in Postoperative Sign/Symptom Relief Following Septoplasty: A Randomized Control Trial2024 · 1 citations
  2. 2Evaluation of clinical efficacy of Tiletamine and Zolazepam in combination with Xylazine or Dexmedetomidine in Butorphanol and Atropine premedicated dogs for performing surgical procedures2024
  3. 3Lignocaine and phenylephrine spray prior to brachycephalic obstructive airway syndrome surgery in dogs reduces postoperative regurgitation: a prospective, randomized, controlled trial2026
  4. 4Oxymetazoline Can Shorten the Time Required for a Bronchoscope to Reach the Vocal Cords in Patients With Turbinate Hypertrophy2026
  5. 5A randomized trial of bupivacaine liposomal injectable suspension shows reduced need for postoperative analgesic rescue in dogs undergoing enucleation2025