Key result
Intramyocardial injection of HMGB1 with Dex-PCL-HEMA/PNIPAAm hydrogel improved cardiac function and reduced collagen content in rat models of myocardial infarction compared to either agent alone.
Why the study?
Does intramyocardial delivery of HMGB1 with a thermosensitive hydrogel improve cardiac function and attenuate remodeling in a rat model of myocardial infarction?
Does intramyocardial delivery of HMGB1 with a thermosensitive hydrogel improve cardiac function and attenuate remodeling in a rat model of myocardial infarction?
Intramyocardial delivery of HMGB1 via a novel thermosensitive hydrogel attenuates cardiac remodeling and improves function post-MI in rats by inducing myocardial regeneration.
Hypothesis-generating for HMGB1-hydrogel in post-MI remodeling; requires validation in larger models before clinical consideration.
BACKGROUND: High-mobility group box 1 (HMGB1), a nuclear protein, has been recently reported to attenuate cardiac remodeling after myocardial infarction (MI). This study was designed to investigate whether this effect could be strengthened by local intramyocardial injection of HMGB1 along with a novel Dex-PCL-HEMA/PNIPAAm hydrogel and ascertain its possible mechanism of action. METHODS: Rat models were induced by coronary artery ligation. Phosphate-buffered solution, Dex-PCL-HEMA/PNIPAAm hydrogel, HMGB1 in phosphate-buffered solution, or HMGB1 in hydrogel was injected into a peri-infarcted area of cardiac tissue immediately after MI. RESULTS: The injection of HMGB1 along with hydrogel improved cardiac function and reduced collagen content. Additionally, the number of c-Kit/Ki67, α-sarcomeric/MEF2C, and α-sarcomeric/Ki67 cells were increased significantly compared with the results of using either agent alone. CONCLUSIONS: HMGB1 injection with Dex-PCL-HEMA/PNIPAAm hydrogel attenuates cardiac remodeling and improves cardiac function after MI by inducing myocardial regeneration.
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He et al. (2012) studied Myocardial Infarction. HMGB1 in Dex-PCL-HEMA/PNIPAAm hydrogel vs. Phosphate-buffered solution, hydrogel alone, or HMGB1 in phosphate-buffered solution was evaluated on Cardiac function and collagen content. Intramyocardial injection of HMGB1 with Dex-PCL-HEMA/PNIPAAm hydrogel improved cardiac function and reduced collagen content in rat models of myocardial infarction compared to either agent alone.
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