Key result
Isometric handgrip exercise during hypoxia enhanced blood pressure, heart rate, muscle sympathetic nerve activity, and ventilation responses compared to hypoxia alone (all P < 0.05).
Why the study?
Does isometric handgrip exercise during isocapnic hypoxia alter cardiorespiratory and sympathetic responses compared to isolated hypoxia or normoxic exercise in healthy subjects?
Population
13 healthy subjects, age 22 +/- 2 yr
Comparison
3 min of isometric handgrip exercise during… vs 3 min of isocapnic hypoxia alone and isometric…
Design
Other, randomized interventions
Follow-up
3 min per intervention
Authors
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May heighten cardiorespiratory stress during hypoxic exercise; hypothesis-generating for patient populations with combined hypoxia and metaboreflex activation.
RCT (n=13)
Randomized
Does isometric handgrip exercise during isocapnic hypoxia alter cardiorespiratory and sympathetic responses compared to isolated hypoxia or normoxic exercise in healthy subjects?
p-value: p=<0.05
Metaboreceptors and chemoreceptors exert differential and interactive effects on cardiorespiratory and sympathetic responses during exercise in hypoxia.
Houssière et al. (2004) conducted an RCT in Healthy (n=13). Isometric handgrip exercise during isocapnic hypoxia vs. Isocapnic hypoxia alone and isometric handgrip in normoxia was evaluated on Blood pressure, heart rate, muscle sympathetic nerve activity (MSNA), and ventilation responses (p=<0.05). Isometric handgrip exercise during hypoxia enhanced blood pressure, heart rate, muscle sympathetic nerve activity, and ventilation responses compared to hypoxia alone (all P < 0.05).
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