What question did this study set out to answer?

Determine whether hyperoxia increases muscle sympathetic nerve activity and blood pressure responses to isometric exercise and isolated muscle metaboreflex activation.

June 13, 2006AJP Heart and Circulatory Physiology

Hyperoxia enhances metaboreflex sensitivity during static exercise in humans

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Why the study?

Does breathing 100% oxygen increase muscle sympathetic nerve activity and mean blood pressure responses to isometric exercise in healthy men?

Population

12 healthy men

Comparison

Breathing 100% oxygen at rest, during isometric… vs Breathing 21% oxygen under the same conditions

Design

Other

Authors

AHAnne HoussièreUniversité Libre de Bruxelles BNB. NajemErasmus Hospital NCNicolas CuylitsLeefmilieu Brussel

Discussion

Member takes

Implication

Hyperoxia may heighten sympathetic and pressor responses to isometric exercise; hypothesis-generating in healthy men, requires patient studies before clinical consideration.

Key Points

Determine whether hyperoxia increases muscle sympathetic nerve activity and blood pressure responses to isometric exercise and isolated muscle metaboreflex activation.
Assessed 12 healthy men breathing normoxic (21% O2) versus hyperoxic (100% O2) air at rest and during isometric handgrip at 30% maximal voluntary contraction.
Followed isometric exercise with 3 minutes of postexercise circulatory arrest to isolate metaboreflex activation in the absence of other reflexes.
Measured muscle sympathetic nerve activity (MSNA), heart rate, mean blood pressure (MBP), blood lactate, and arterial oxygen saturation.
At rest, hyperoxia decreased MSNA, heart rate, MBP, and blood lactate while increasing arterial oxygen saturation compared with normoxia (all P < 0.05).
During isometric handgrip, hyperoxia induced significantly larger increases in MSNA (255 ± 100% vs. 211 ± 80%, P = 0.04) and MBP (33 ± 9 mmHg vs. 26 ± 10 mmHg, P = 0.03) than normoxia.
During postexercise circulatory arrest, both MSNA and MBP remained elevated to a significantly greater extent in hyperoxia than in normoxia (both P < 0.05).

Structured PICO

Does breathing 100% oxygen increase muscle sympathetic nerve activity and mean blood pressure responses to isometric exercise in healthy men?

Population

12 healthy men

Intervention

Breathing 100% oxygen (hyperoxia) at rest, during isometric handgrip at 30% of maximal voluntary contraction, and during 3 min of postexercise circulatory arrest

Comparator

Breathing 21% oxygen (normoxia) under the same conditions

Outcome

Muscle sympathetic nerve activity (MSNA) and mean blood pressure (MBP) responsessurrogate

Hyperoxia enhances sympathetic and blood pressure reactivity to metaboreflex activation during static exercise, despite reduced lactic acid production.

Cite This Study

Houssière et al. (2006) studied this question.

synapsesocial.com/papers/6a8931cecd9902a7ca1282bb https://doi.org/10.1152/ajpheart.01168.2005

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Implication

Hyperoxia may heighten sympathetic and pressor responses to isometric exercise; hypothesis-generating in healthy men, requires patient studies before clinical consideration.

Hyperoxia enhances metaboreflex sensitivity during static exercise in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hyperoxia enhances metaboreflex sensitivity during static exercise in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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