Access to the homochiral diazepanone core of liposidomycins has been carried out through the regiospecific nucleophilic opening of an enantiomerically pure α-amino-β,γ-epoxy-acid precursor, by an L-amino acid derivative, on one hand and cyclisation by a peptidic coupling reaction, on the other hand.
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Gravier‐Pelletier et al. (1997) studied this question.
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