Key result
Vagus nerve stimulation elicited responses in some post-inspiratory and stage II expiratory neurones, with short latencies (< 2 ms) indicating a disynaptic pathway.
Population
Anaesthetized rats (106 respiratory neurones in the intermediate region of the nucleus ambiguus)
Design
Preclinical
Authors
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Supports disynaptic vagal input to expiratory neurons in animals; leaves open translation to human respiratory control.
The study demonstrates that vagal afferents act on post-inspiratory neurones via a disynaptic pathway, supporting the functional division of expiration.
Parkes et al. (1994) studied this question. Vagus nerve stimulation was evaluated on Neuronal response to vagus nerve stimulation. Vagus nerve stimulation elicited responses in some post-inspiratory and stage II expiratory neurones, with short latencies (< 2 ms) indicating a disynaptic pathway.
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