Key result
Nifedipine and prazosin as second-line agents for severe hypertension in pregnancy yielded comparable antenatal days gained (P=0.9), though prazosin was associated with more intrauterine deaths.
Why the study?
Does nifedipine compared to prazosin improve antenatal days gained and perinatal survival in pregnant women with severe hypertension uncontrolled by methyldopa?
Population
Women with early, severe pre-eclampsia or hypertension in pregnancy, whose blood pressure could not be…
Comparison
Nifedipine given and increased in a stepwise… vs Prazosin given and increased in a stepwise…
Design
RCT, Randomised
Follow-up
Until delivery
Authors
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Nifedipine preferred over prazosin for severe hypertension in pregnancy to minimize intrauterine deaths; extends RCT data on second-line agents after methyldopa.
RCT
No
Does nifedipine compared to prazosin improve antenatal days gained and perinatal survival in pregnant women with severe hypertension uncontrolled by methyldopa?
p-value: p=0.9
Nifedipine and prazosin provide comparable antenatal days gained as second-line agents for severe hypertension in pregnancy, but prazosin is associated with a higher risk of intrauterine deaths and pulmonary edema.
Hall et al. (2000) conducted an RCT in Early, severe pre-eclampsia or hypertension in pregnancy. Nifedipine vs. Prazosin was evaluated on Antenatal days gained (p=0.9). Nifedipine and prazosin as second-line agents for severe hypertension in pregnancy yielded comparable antenatal days gained (P=0.9), though prazosin was associated with more intrauterine deaths.
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