Key result
Examination session stress caused significant but reversible activation of the hemostasis system in healthy students, with female students exhibiting higher fibrinogen levels than males.
Why the study?
Student examination sessions act as a stress factor causing physiological changes driven by cortisol release, prompting evaluation of red blood and hemostasis parameters across study periods by gender.
Does examination stress alter red blood indicators and hemostasis in healthy students?
Observational (n=100)
Does examination stress alter red blood indicators and hemostasis in healthy students?
Examination stress induces transient, non-pathological activation of the hemostasis system in healthy students, with gender-specific differences such as higher fibrinogen in females.
Academic stress effects on hemostasis remain hypothesis-generating in students; larger studies needed before any cardiovascular risk implications.
BACKGROUND: An examination session in students can be considered as a manifestation of a stress factor. As a result, during this period there are changes in the basic physiological parameters of students, which are due to the release of a large amount of cortisol. AIM: To evaluate the indicators of red blood and some indicators of the aggregate state of blood in students in different periods of study, taking into account gender differences. MATERIALS AND METHODS: The study design included 100 examined. Of the total number of examined relatively healthy (did not make complaints, were not on the dispensary register and did not have established diagnoses) 100 people (50 men and 50 women). The absence of diseases was confirmed by medical documentation, since all persons of this group underwent an annual preventive examination for admission to study. Included in the study were volunteers aged between 18 and 30 years who, based on medical records, had no acute or chronic illness and gave voluntary consent to participate in the study. The average age was 23 3 years. RESULTS: Based on the presented study, it was found that the stressful situation caused by the examination session leads to pronounced changes in the hemostasis system, which may be a manifestation of endothelial dysfunction, while there are differences between these changes in men and women, which are manifested by differences in indicators of red blood, rheological properties of blood, endothelin levels, von Willebrand factor, tPA-PAI-1 complexes, antithrombin III. In addition, when comparing these indicators by gender, the predominance of fibrinogen levels in female students over men was noted. However, despite the pronounced changes in the hemostasis system, they were not critical and did not lead to the development of pathological conditions, moreover, as further studies showed, these changes were quickly stopped when the stress factor was stopped. As our research shows, after the end of the session, in the period of 7-8 days, both men and women, all analyzed indicators returned to physiologically normal indicators. CONCLUSIONS: Thus, the conducted studies show that during the examination session, which can be regarded as a stressful situation, there is a significant activation of the hemostasis system, while there are certain differences related to gender. Thus, the predominance of fibrinogen levels in female students over men was established.
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Maslyakov et al. (2021) conducted an observational in Healthy (examination stress) (n=100). Examination session stress vs. Post-session period / Male students was evaluated on Indicators of red blood and hemostasis system. Examination session stress caused significant but reversible activation of the hemostasis system in healthy students, with female students exhibiting higher fibrinogen levels than males.
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