Key result
Trypanosoma cruzi infection is linked to functional changes in vasoactive mediators like endothelin-1 and kinins, suggesting potential therapeutic targets for Chagas disease cardiomyopathy.
Population
Chagas' disease (cardiomyopathy caused by Trypanosoma cruzi infection)
Design
Review
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May offer novel targets in Chagas cardiomyopathy; leaves open whether modulating endothelin-1 or kinins improves outcomes.
Understanding the role of vasoactive mediators like endothelin-1 and kinins in Chagas' disease may provide new therapeutic targets for the associated cardiomyopathy.
A 2003 study conducted a review in Chagas disease. Trypanosoma cruzi infection was evaluated. Trypanosoma cruzi infection is linked to functional changes in vasoactive mediators like endothelin-1 and kinins, suggesting potential therapeutic targets for Chagas disease cardiomyopathy.
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