Key result
Anterior shear wave speed assessed by ultrafast imaging was significantly associated with reference measures of arterial stiffness, including carotid-to-femoral pulse wave velocity (r=0.66, p<0.001).
Why the study?
Does shear wave elastography and ultrafast imaging of the carotid artery pulse wave correlate with reference techniques for assessing arterial stiffness in normotensive and hypertensive patients?
Cross-Sectional (n=56)
Does shear wave elastography and ultrafast imaging of the carotid artery pulse wave correlate with reference techniques for assessing arterial stiffness in normotensive and hypertensive patients?
Effect estimate: r = 0.66
p-value: p=<0.001
Shear wave speed in the anterior carotid wall measured by ultrafast imaging correlates well with reference techniques for assessing arterial stiffness.
Supports carotid shear wave elastography for stiffness assessment; leaves open clinical utility pending prospective validation.
Shear wave elastography and ultrafast imaging of the carotid artery pulse wave were performed in 27 normotensive participants and 29 age- and sex-matched patients with essential hypertension, and compared with reference techniques: carotid-femoral pulse wave velocity (cfPWV) determined via arterial tonometry and carotid stiffness (carPWV) determined via echotracking. Shear wave speed in the carotid anterior (a-SWS) and posterior (p-SWS) walls were assessed throughout the cardiac cycle. Ultrafast PWV was measured in early systole (ufPWV-FW) and in end-systole (dicrotic notch, ufPWV-DN). Shear wave speed in the carotid anterior appeared to be the best candidate to evaluate arterial stiffness from ultrafast imaging. In univariate analysis, a-SWS was associated with carPWV (r = 0.56, p = 0.003) and carotid-to-femoral PWV (r = 0.66, p < 0.001). In multivariate analysis, a-SWS was independently associated with age (R² = 0.14, p = 0.02) and blood pressure (R² = 0.21, p = 0.004). Moreover, a-SWS increased with blood pressure throughout the cardiac cycle and did not differ between normotensive participants and patients with essential hypertension when compared at similar blood pressures.
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Marais et al. (2019) conducted a cross-sectional in Essential hypertension (n=56). Shear wave elastography and ultrafast pulse wave imaging vs. Reference techniques (carotid-femoral pulse wave velocity and echotracking) was evaluated on Association of anterior shear wave speed (a-SWS) with carotid-to-femoral pulse wave velocity (cfPWV) (r = 0.66, p=<0.001). Anterior shear wave speed assessed by ultrafast imaging was significantly associated with reference measures of arterial stiffness, including carotid-to-femoral pulse wave velocity (r=0.66, p<0.001).
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