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A new ditopic host molecule (3), composed of the macromonocyclic 1,4,7,10,13,16-hexa-azacyclo-octadecane (1) and the macrocyclic polyether benzo-15-crown-5 (2) covalently linked, forms stable 1 : 1 complexes with zwitterionic molecules such as amino acids, peptides, and dopamine in aqueous solution at neutral pH.
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Kimura et al. (1986) studied this question.
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