Key result
A new strain-energy function integrated into a three-dimensional mechano-chemical model successfully simulated the spatio-temporal contraction patterns of cardiac myocytes driven by calcium waves.
Population
Isolated cardiac myocytes (computational model)
Comparison
Integrated mechano-chemical three-dimensional… vs Experimental stress-strain curves…
Design
Preclinical
Authors
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May inform future myocyte modeling; leaves open human translation from this animal study framework.
The proposed integrative mechano-chemical model provides a comprehensive framework for analyzing active stress regulation and mechano-transduction in cardiac myocytes.
Tracqui et al. (2009) studied Cardiac myocyte contraction. Integrated mechano-chemical three-dimensional model with a new strain-energy function was evaluated on Contraction patterns of cardiac myocytes. A new strain-energy function integrated into a three-dimensional mechano-chemical model successfully simulated the spatio-temporal contraction patterns of cardiac myocytes driven by calcium waves.
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