Key result
A linear equation prediction model based on five common differentially expressed genes achieved an area under the ROC curve of 0.831 with 80% sensitivity and specificity for predicting cardiac hypertrophy.
Population
35 heart samples harvested from Wistar rats on postoperative days 1, 6, and 42 following aorta ligation and…
Comparison
Aorta ligation to induce cardiac hypertrophy vs Sham operation
Design
Preclinical
Follow-up
42 days
Authors
Loading...
Rat gene model forecasts hypertrophy trends; leaves open human translation and clinical validation.
Effect estimate: AUC 0.831
A mathematical model based on microarray data identified five key genes and demonstrated moderate accuracy in predicting gene expression trends in a rat model of cardiac hypertrophy.
Ma et al. (2016) studied Cardiac hypertrophy (n=35). Aorta ligation (cardiac hypertrophy model) vs. Sham operation was evaluated on Accuracy of the linear discriminant analysis prediction model (Area under the ROC curve) (AUC 0.831). A linear equation prediction model based on five common differentially expressed genes achieved an area under the ROC curve of 0.831 with 80% sensitivity and specificity for predicting cardiac hypertrophy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: