Key result
Perindopril plus Amlodipine single pill combination significantly reduced systolic and diastolic blood pressures by 24.6 mmHg and 12.7 mmHg respectively at 12 weeks compared to baseline.
Why the study?
No large-scale study had demonstrated the efficacy of single pill combination antihypertensive medications in a black African population.
Does perindopril plus amlodipine single pill combination reduce blood pressure in black African hypertensive patients?
Observational (n=937)
Open-label
Yes
Does perindopril plus amlodipine single pill combination reduce blood pressure in black African hypertensive patients?
Mean Difference: -24.6
p-value: p=<0.0001
Perindopril plus amlodipine single-pill combination provides clinically meaningful and significant blood pressure reductions and is well tolerated in black African hypertensive patients.
May support perindopril-amlodipine SPC in black African hypertensives; leaves open randomized confirmation of efficacy.
Background: There is no large-scale study that has shown the efficacy of single pill combination (SPC) antihypertensive medications in black African population. We therefore evaluated the blood pressure (BP) lowering efficacy and the tolerability of Perindopril plus Amlodipine SPC in black African patients. Methods: It was a multi-centre, prospective, observational programme among hypertensive patients using different doses of Perindopril and Amlodipine. Primary endpoint was assessed as the change in mean sitting systolic and diastolic BPs from baseline to 3 months. Results: 937 patients (55.7% female) were analysed, and the mean age was 56.4 ± 12.7 years. Systolic and diastolic BPs were significantly reduced by 17.3/ 9.4mmHg, 21.1/10.8mmHg mmHg and 24.6/12.7mmHg at 4, 8 and 12 weeks respectively compared to baseline value (p<0.0001). Dry cough was seen in 0.64% and angioedema 0.1% of the patients. Conclusions: Perindopril plus Amlodipine SPC provided clinically meaningful BP reductions and is well tolerated in a black African population.
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Ojji et al. (2022) conducted an observational in Hypertension (n=937). Perindopril plus Amlodipine single pill combination vs. Baseline was evaluated on Change in mean sitting systolic and diastolic blood pressures from baseline to 12 weeks (MD -24.6 mmHg (systolic) and -12.7 mmHg (diastolic), p=<0.0001). Perindopril plus Amlodipine single pill combination significantly reduced systolic and diastolic blood pressures by 24.6 mmHg and 12.7 mmHg respectively at 12 weeks compared to baseline.
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