Key result
The RRV-TV vaccine demonstrated 70% efficacy against the P[8], G1 rotavirus genotype combination during the first year of follow-up (p<0.009), but no efficacy was observed in the second year.
Why the study?
Does the RRV-TV vaccine provide efficacy against specific P and G rotavirus genotypes?
Does the RRV-TV vaccine provide efficacy against specific P and G rotavirus genotypes?
The RRV-TV vaccine demonstrated significant efficacy against specific rotavirus genotypes during the first year of follow-up, but this protection did not persist into the second year.
Answers are grounded in this paper and cite their sources.
May support short-term genotype-specific protection with RRV-TV; leaves open durability and need for confirmatory trials.
To determine the efficacy of a reassortant rhesus-human tetravalent rotavirus vaccine (RRV-TV) (4 x 10(4) pfu/dose) against P and G rotavirus genotypes, 90 positive samples were tested using reverse transcription-polymerase chain reaction. The efficacy of the RRV-TV vaccine against P[8] and G1 individually or in binary combination P[8], G1 was 72 per cent (p < 0.005) 61 per cent (p < 0.013), and 70 per cent (p < 0.009), respectively, only for the first year of follow-up. In the second year, as well as after 2 years of follow-up, no efficacy was observed to these genotypes. These data indicate that further studies with rotavirus vaccines should focus on the molecular characterization of rotaviruses genotypes, in order to see whether or not cross-protection among different G and P genotypes may occur as a result of common bearing of VP4 specificities.
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Joana D’Arc Pereira Mascarenhas (2002) studied Rotavirus infection. Tetravalent Rhesus-human Rotavirus Vaccine (RRV-TV) was evaluated on Efficacy against binary combination P[8], G1 rotavirus genotypes in the first year (70% efficacy, p=< 0.009). The RRV-TV vaccine demonstrated 70% efficacy against the P[8], G1 rotavirus genotype combination during the first year of follow-up (p<0.009), but no efficacy was observed in the second year.
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