Key result
Hypertensive patients with an ascending aortic aneurysm had significantly higher augmentation index values compared to controls (27 vs. 22.7, p<0.05), suggesting elevated aortic stiffness.
Why the study?
It was unknown how central blood pressure, pulse pressure, and arteriography-derived arterial stiffness parameters compare between hypertensive patients with versus without concomitant ascending aortic aneurysms.
Does the presence of ascending aortic aneurysm correlate with increased arterial stiffness parameters measured by oscillometric arteriography in hypertensive patients?
Observational (n=83)
No
Does the presence of ascending aortic aneurysm correlate with increased arterial stiffness parameters measured by oscillometric arteriography in hypertensive patients?
Absolute Event Rate: 27% vs 22.7%
p-value: p=<0.05
Hypertensive patients with ascending aortic aneurysms exhibit higher augmentation index values, suggesting a potential relationship between aneurysm development and elevated aortic stiffness.
Higher augmentation index was associated with ascending aortic aneurysm in hypertensives; leaves open whether stiffness parameters improve risk stratification.
OBJECTIVE: The aim of this study was to compare central blood pressure, central pulse pressure, and parameters like augmentation index and pulse wave velocity, which are used to evaluate arterial stiffness using an oscillometric method called arteriography, among hypertensive patients with and without concomitant ascending aortic aneurysms. METHODS: This research was conducted as a single-center and prospective study. A total of 83 patients were included in this study, including 44 consecutive patients with hypertension diagnosed and an ascending aortic diameter of 40 mm or more detected by 2D transthoracic echocardiography, and 39 controls with hypertension diagnosed and a normal ascending aortic diameter. RESULTS: E/e' ratio was found to be significantly higher in the aneurysm group (9.05±2.24 vs. 7.75±1.94, p<0.05). The difference between peripheral and central systolic blood pressures was found to be significantly lower in the aneurysm group compared to the control group (9.3±4.5 vs. 11.8±4.1, p<0.05, respectively). Among the examined arterial stiffness parameters, augmentation index values were significantly higher in the aneurysm group (27±8.7 vs. 22.7±9.6, p<0.05), while pulse wave velocity did not show a statistically significant difference between the groups (8.85±1.85 vs. 8.59±1.19, p>0.05, respectively). CONCLUSION: Our study suggests that a potential relationship between the development of ascending aortic aneurysm and elevated aortic stiffness in hypertensive patients.
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Arpa et al. (2025) conducted an observational in Hypertension and ascending aortic aneurysm (n=83). Ascending aortic aneurysm vs. Normal ascending aortic diameter was evaluated on Augmentation index (p=<0.05). Hypertensive patients with an ascending aortic aneurysm had significantly higher augmentation index values compared to controls (27 vs. 22.7, p<0.05), suggesting elevated aortic stiffness.
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