Key result
The proposed stimulatory role of soluble guanylyl cyclase (sGC) in platelets is disputed, as recent claims contrast with numerous previous studies.
This letter to the editor debates the basic science mechanisms of the NO/sGC/cGMP/PKG pathway in platelet activation.
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Gambaryan et al. (2012) studied this question. The proposed stimulatory role of soluble guanylyl cyclase (sGC) in platelets is disputed, as recent claims contrast with numerous previous studies.
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