Key result
Studies with a quality score ≥0.60 were significantly more likely to identify a therapeutic window for haloperidol compared to lower-quality studies (53% vs 0%, p=0.002).
Why the study?
Is there a relationship between haloperidol blood levels and clinical efficacy, and is this relationship dependent on study quality?
Population
33 studies analyzing the relationship between haloperidol blood levels and clinical outcomes in patients…
Design
Systematic_review
Authors
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Higher-quality studies support a haloperidol therapeutic window; extends evidence for concentration-guided dosing while flagging study quality as a key confounder.
Systematic Review (n=33)
Is there a relationship between haloperidol blood levels and clinical efficacy, and is this relationship dependent on study quality?
Absolute Event Rate: 53% vs 0%
p-value: p=0.002
Higher quality studies are significantly more likely to identify a therapeutic window for haloperidol, suggesting that an upper limit for its clinical efficacy exists.
Oliveira et al. (1995) conducted a systematic review in Schizophrenia, schizophreniform, and schizoaffective disorders (n=33). Study quality score ≥ 0.60 vs. Study quality score < 0.60 was evaluated on Ability to show a therapeutic window (p=0.002). Studies with a quality score ≥0.60 were significantly more likely to identify a therapeutic window for haloperidol compared to lower-quality studies (53% vs 0%, p=0.002).