Key result
High-dose (0.40 mg/kg) and low-dose (0.15 mg/kg) haloperidol showed no difference in overall clinical improvement in schizophrenic patients, though the high-dose group had faster initial improvement.
Why the study?
Does high-dose haloperidol improve clinical response compared to low-dose haloperidol in acute schizophrenic patients?
Population
Acute schizophrenic patients
Comparison
Haloperidol high dose (0.40 mg/kg) vs Haloperidol low dose (0.15 mg/kg)
Design
Other, double-blind
Follow-up
8 days
Authors
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High- and low-dose haloperidol yield similar overall response in acute schizophrenia; leaves open plasma level-guided dosing and initial response kinetics.
RCT
Double-blind
Does high-dose haloperidol improve clinical response compared to low-dose haloperidol in acute schizophrenic patients?
Haloperidol plasma levels after a test dose may correlate with clinical improvement in patients receiving low-dose therapy, but its overall predictive utility remains uncertain.
Müller‐Spahn et al. (1988) conducted an RCT in Schizophrenia. Haloperidol vs. 0.15 mg/kg was evaluated on Clinical improvement. High-dose (0.40 mg/kg) and low-dose (0.15 mg/kg) haloperidol showed no difference in overall clinical improvement in schizophrenic patients, though the high-dose group had faster initial improvement.
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