Key result
Rapid haloperidol response is linked to lower plasma homovanillic acid concentrations at week 4.
Why the study?
What are the clinical and biochemical correlates of rapid neuroleptic response in male schizophrenic inpatients treated with haloperidol?
Population
16 male schizophrenic inpatients
Design
Cohort
Follow-up
4 weeks
Authors
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Lower week-4 pHVA was associated with rapid haloperidol response in schizophrenia; hypothesis-generating for biomarker utility and requires prospective validation before clinical use.
Observational (n=16)
What are the clinical and biochemical correlates of rapid neuroleptic response in male schizophrenic inpatients treated with haloperidol?
Rapid response to haloperidol in male schizophrenic patients is associated with lower plasma homovanillic acid concentrations at 4 weeks, but not with baseline demographics or symptom severity.
Petrie et al. (1990) conducted an observational in schizophrenia (n=16). Haloperidol vs. Non-rapid responders was evaluated on plasma homovanillic acid (pHVA) concentrations during week 4. Rapid responders to haloperidol treatment had significantly lower plasma homovanillic acid concentrations compared to non-rapid responders during week 4.
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