Key result
Sympathetic nervous activity, measured by equivalent stimulation frequency, was markedly increased in DOC hypertensive rats but decreased or unchanged in renal hypertensive rats compared to controls.
Population
Male rats of the Donryu strain, including renal hypertensive models, DOC hypertensive models, and…
Comparison
Induction of hypertension via DOC-salt treatment… vs Normotensive intact controls and unilaterally…
Design
Preclinical
Follow-up
2 or 10 weeks
Authors
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Hypothesis-generating for differential sympathetic roles across rat hypertension models; does not inform human therapy selection.
The sympathetic nervous system participates significantly in the pathogenesis of DOC-salt hypertension but not in renal hypertension in rat models.
Iriuchijima et al. (1975) studied Renal and DOC hypertension (n=100). Deoxycorticosterone (DOC)-salt treatment or renal clipping vs. Intact or unilaterally nephrectomized controls was evaluated on Equivalent stimulation frequency (ESF) of the splanchnic nerve. Sympathetic nervous activity, measured by equivalent stimulation frequency, was markedly increased in DOC hypertensive rats but decreased or unchanged in renal hypertensive rats compared to controls.
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