Why the study?
Vitamin D influences the renin-angiotensin system, prompting investigation into the effect of vitamin D supplementation and vitamin D receptor gene polymorphisms on outcomes and markers in patients with acute coronary syndrome.
Does vitamin D supplementation improve echocardiographic parameters and reduce markers of cardiac fibrosis in patients with acute coronary syndrome?
Comparison
ACS standard therapy plus vitamin D vs ACS standard therapy alone
Design
Randomized controlled trial
Follow-up
24 months
Key result
Vitamin D supplementation in patients with acute coronary syndrome significantly reduced end systolic and diastolic volumes (p=0.0075 and 0.002) and cardiac fibrosis markers.
Authors
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Supports adjunctive vitamin D in ACS to improve remodeling surrogates; extends prior data with RCT evidence on LV volumes and fibrosis markers.
RCT (n=250)
Does vitamin D supplementation improve echocardiographic parameters and reduce markers of cardiac fibrosis in patients with acute coronary syndrome?
Vitamin D supplementation in patients with acute coronary syndrome may improve echocardiographic parameters and reduce surrogate markers of cardiac fibrosis and epigenetic noncoding RNAs.
Sarhan et al. (2023) conducted an RCT in Acute coronary syndrome (n=250). Vitamin D supplementation vs. ACS standard therapy alone was evaluated on Cardiac fibrosis markers, echocardiographic parameters, and epigenetic markers. Vitamin D supplementation in patients with acute coronary syndrome significantly reduced end systolic and diastolic volumes (p=0.0075 and 0.002) and cardiac fibrosis markers.
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