Why the study?
Is there an association between vitamin D levels, VDR polymorphisms, and biomarkers of left ventricular remodeling in patients with systolic heart failure?
Population
30 patients with systolic heart failure undergoing right heart catheterization, mean EF 17% ± 8%.
Comparison
Presence of VDR haplotype block or vitamin D… vs Absence of VDR haplotype block or vitamin D…
Design
Cross-sectional
Key result
The CGA haplotype of the vitamin D receptor was associated with significantly higher log PIIINP values compared to patients without the haplotype (1.74 vs 1.36 mcg/mL, P=0.0041).
Authors
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May inform fibrosis risk stratification in systolic HF; leaves open VDR role in remodeling.
Cross-Sectional (n=30)
Is there an association between vitamin D levels, VDR polymorphisms, and biomarkers of left ventricular remodeling in patients with systolic heart failure?
Absolute Event Rate: 1.74% vs 1.36%
p-value: p=.0041
The CGA haplotype of the vitamin D receptor is associated with higher levels of PIIINP, a biomarker for collagen type III synthesis, suggesting a genetic role in myocardial fibrosis in systolic heart failure.
Dorsch et al. (2014) conducted a cross-sectional in Systolic heart failure (n=30). CGA haplotype of the vitamin D receptor vs. Patients without the CGA haplotype was evaluated on log PIIINP values (mcg/mL) (p=.0041). The CGA haplotype of the vitamin D receptor was associated with significantly higher log PIIINP values compared to patients without the haplotype (1.74 vs 1.36 mcg/mL, P=0.0041).
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