Effect of vitamin D supplementation for major adverse cardiovascular events: A meta-analysis based on randomized controlled trials

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Meta-analysis shows vitamin D supplementation does not significantly reduce MACEs, indicating BMI may influence outcomes.

Pooled results reveal no significant difference in major adverse cardiovascular events between vitamin D supplementation and control groups.
The analysis included five randomized controlled trials, focusing on hazard ratios to assess incidence rates.
While vitamin D showed a lower incidence of myocardial infarction for some subgroups, the overall results did not achieve statistical significance.
Overweight or obese individuals may benefit from vitamin D to reduce the risk of major adverse cardiovascular events, particularly those with a BMI ≥25 kg/m2.

Cheng et al. (2025) studied this question.

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View Full Paper

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Authors

Meta-analysis shows vitamin D supplementation does not significantly reduce MACEs, indicating BMI may influence outcomes.

Pooled results reveal no significant difference in major adverse cardiovascular events between vitamin D supplementation and control groups.
The analysis included five randomized controlled trials, focusing on hazard ratios to assess incidence rates.
While vitamin D showed a lower incidence of myocardial infarction for some subgroups, the overall results did not achieve statistical significance.
Overweight or obese individuals may benefit from vitamin D to reduce the risk of major adverse cardiovascular events, particularly those with a BMI ≥25 kg/m2.

Cheng et al. (2025) studied this question.

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