Key result
Cardiovascular autonomic neuropathy affects 64% of T2D patients and is linked to higher serum leptin.
Why the study?
Cardiovascular autonomic neuropathy is a major cause of morbidity and mortality in diabetes due to arrhythmia risk, motivating estimation of its prevalence and association with serum omentin and leptin.
Cross-Sectional (n=100)
No
Cardiovascular autonomic neuropathy is highly prevalent in patients with type 2 diabetes and is associated with elevated serum leptin levels.
Answers are grounded in this paper and cite their sources.
High CAN prevalence in T2D may support screening consideration; leptin association is hypothesis-generating and requires prospective validation.
Cardiovascular autonomic neuropathy (CAN) is a major cause of morbidity and mortality in patients with diabetes as it is associated with a high risk of cardiac arrhythmias. OBJECTIVES: This prospective observational cross-sectional study was done to estimate the prevalence of CAN in patients with type 2 diabetes and to study its association with serum omentin and leptin levels. METHODS: This study included 100 patients with type 2 diabetes mellitus attending the outpatient department of JIPMER Hospital, Pondicherry, India, from January 2017 to December 2018. CAN was assessed in all subjects using four cardiovascular autonomic function tests. Blood samples were collected and stored at - 80°C to estimate leptin and omentin levels. Comparison of leptin and omentin levels was done between diabetic patients with and without CAN. RESULTS: CAN was present in 64% of the study subjects. Serum leptin levels were significantly higher in patients with CAN, whereas omentin levels, though elevated in those with CAN, were not statistically significant in diabetic patients without CAN. CONCLUSION: There is a high prevalence of CAN in patients with type 2 diabetes mellitus. Leptin levels were elevated in these patients, whereas omentin levels were not significantly different between diabetic patients with and without CAN.
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Mehalingam et al. (2020) conducted a cross-sectional in Type 2 diabetes mellitus (n=100). Cardiovascular autonomic neuropathy (CAN) vs. Diabetic patients without CAN was evaluated on Serum leptin levels (median ng/mL) (p=<0.001). Cardiovascular autonomic neuropathy was present in 64% of patients with type 2 diabetes, and these patients had higher serum leptin levels.
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